Of all intoxications, salicylates is one of the most important to understand. These cases can unravel rapidly, with fatal outcome. However, with prompt management most patients will do fine. Treatment depends on a solid grasp of the underlying chemistry and renal physiology.
The surviving sepsis campaign (SSC) has had substantial problems dating back to its inception. The original backbone of the guidelines was a single-center trial by Rivers, which has largely been debunked.1–4 Initially the SSC was slow to let go of invasive early goal-directed therapy. The SSC has finally started eliminating older dogma (e.g., superior vena cava […]
February 7th 2019 marked a auspicious day in the history of the NEJM and its relationship with the pharmaceutical industry. In 2015, the NEJM shifted their significant weight in support of a strong union between industry and medicine1,2,3. With the simultaneous publication of four pharmaceutical sponsored trials, each brimming with its own unique form of […]
by Howard Greller We rarely stop and appreciate the beauty that is reflected in our physiology. It’s not until something goes wrong that we recognize how well things were working. For example, our brains . . . An analogy I like is that our brains are like a car (I definitely need to upgrade to […]