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PulmCrit – Preview of Lopinavir/Ritonavir efficacy in COVID-19?
background Lopinavir/Ritonavir (tradename KALETRA) is a combination of protease inhibitors typically used in HIV, including post-exposure prophylaxis (lopinavir is the actual antiviral agent, with ritonavir functioning to inhibit metabolism of lopinavir, thereby boosting levels of lopinavir). In vitro, Lopinavir/Ritonavir has activity against SARS-CoV-1 and functions synergistically with ribavirin (the addition of ribavirin increases Lopinavir’s potency […]
IBCC: COVID-19
Friends, As COVID-19 has exploded, so has the amount of information about COVID-19. There are currently over 700 publications regarding coronavirus listed in PubMed within the past few months. More are being released daily. Many haven’t been catalogued on PubMed yet. This chapter will attempt to synthesize the latest and most important information on COVID-19. […]
Tox and Hound – Love and Half-Life*
by Sarah Shafer *Not the video game I’ve gotten some version of this call many times in my budding career as a medical toxicologist: “Hello, we have a something-year-old patient in the ER who overdosed on ______ (fill in the blank) medication. How long do we need to watch them before we can medically clear […]
PulmCrit- Nonsedation in ventilated patients: Two dueling RCTs
A new study in NEJM compared nonsedation with light sedation in ventilated ICU patients. This is a follow-up study, aimed at clarifying the results of a prior trial at the same center. To best understand the current study, we need to start with the first trial… Strom et al. 2010: A protocol of no sedation […]
PulmCrit- My favorite 20 abstracts from SCCM
The Society of Critical Care Medicine published over 1,800 abstracts to go along with their latest conference. I sifted through them to come up with my favorite 20. Kudos to all the authors on creating diverse and thoughtful work – the future of critical care is indeed bright! The abstracts are divided into six groups: […]