Epinephrine has been a fundamental therapeutic agent in the management of cardiac arrest since the inception of advanced life support. Despite its ubiquitous use, this practice has never been supported by high quality evidence. With the publication of the PARAMEDIC-2 trial by Perkins et al1, we are now far closer to understanding the true value […]
Metabolic resuscitation for sepsis is currently quite controversial. Marik et al. published a before-after study in 2017 describing the combination of hydrocortisone, ascorbate, and thiamine for septic shock. That study incited a media storm of surprising intensity. Currently, several multi-center RCTs are underway to answer this question more definitively. In the interim, some additional before/after trials may emerge. These studies likely won’t answer the question, but they may provide us with some clues about whether metabolic resuscitation is on the right track.
. . . or How I Learned to Stop Worrying and Love My Cilice. Join Dan (@drusyniak) &howard (@heshiegreshie) as they explore the exceptions to dose response with Dr. Andrew Stolbach (@toxicologist12). Learn about hormesis, hysteresis, what a peck is and why Dan insists on wearing a hair shirt. Delicious Links Effects of Cobalt-60 Exposure […]