In 2015 I wrote this post on ACEi-induced angioedema. I still think it was a pretty good post (particularly for 2015), but it’s become increasingly clear recently that the post was fundamentally flawed. Let’s try to straighten this out. old model of bradykinin-mediated angioedema This is a conceptual model of how bradykinin-mediated angioedema occurs. Several […]
The timing of basal insulin administration in DKA has been controversial for years. I posted the following poll on twitter recently to get a sense of current opinion on this: So, it seems that the majority of people are using traditional management (wait for the anion gap to close, give basal insulin, then shut off […]
When you’re having a bad day, consider the teratogenic effects of the Veratrum alkaloid, cyclopamine. Scientists say that an attempt to understand sodium channel openers, in and of itself, may produce similar effects. The Cardiovascular Toxicity of Plant Sodium Channel Openers Mad Honey, Cyclopic Ruminants, Sneezing Powder, and Herbal Death Grayanotoxins, Veratrum Alkaloids, and Aconitum […]
Severe hemoptysis is a true challenge. Due to the rarity of this condition, there is little high-quality data on it. So you can’t become a hemoptysis whisperer by reading books. Unfortunately, due to the rarity of the condition it’s also difficult to accumulate clinical experience.