PulmCrit (EMCrit)

Massive Transfusion Protocols have attracted substantial attention over the past several years, so most folks will be familiar with the general concepts.  This chapter reviews a variety of details which may be essential to the success of an MTP – yet can easily get lost in the chaos. The IBCC chapter is located 👉 here. […]

With the publication of the SOLIDARITY trial, there is increasing consensus that remdesivir doesn’t affect mortality.  However, there continues to be debate about whether remdesivir affects hospital length of stay.  Let’s dig into the data here to try to reconcile differences between ACTT-1 and SOLIDARITY.  Did ACTT-1 actually show that remdesivir reduces the hospital length […]

The closed mouth catches no flies Benjamin Franklin, Poor Richard’s Almanac, 1742 We’re hopefully nearing the end of the COVID pandemic, with vaccines coming soon.  Unfortunately, vaccines won’t be able to bail us out this winter.  Neither will fancy designer pharmaceuticals.  The main interventions necessary to keep us safe for now are basic public health […]

2020 has been a weird year by any standard.  So, I shouldn’t be surprised that the bamlanivimab story is so weird.  But still.  Anyhow, if you’re ready to go down the rabbit hole, here we go… derivation and early testing The story begins with Eli Lilly designing a monoclonal anti-spike antibody to neutralize COVID-19. The […]

We are continually tasked with triaging COVID patients, a situation which will become more complex as the numbers continue to rise.  This involves making educated guesses about which patients are most likely to deteriorate, and which patients may benefit most from critical care.  That’s enormously difficult. At this point, we’re quite familiar with individual risk […]