The importance of avoiding and treating renal failure cannot be overstated. The kidneys are delicate organs, often the first to be injured by systemic hypoperfusion or other insults. Severe renal dysfunction leads to a cascade of badness, promoting the failure of other organs and eventual spiraling into multi-organ failure.1 Alternatively, if we are can defend […]
7 Cyanide Wishes and Thallium Dreams! Howard – The story of the year? The Tox and The Hound! Toxicology’s foray into the world of FOAM has had an auspicious start. I am obviously biased, but I think that we have a phenomenal team and have put forth some outstanding content. From toxicology·fundamentals, to the classics (including […]
There are a number of reasons that an idea may be impossible to test scientifically. Perhaps the disease state that the idea applies to is extremely rare. Perhaps it is logistically impossible to test the idea, due to issues with blinding or time constraints. This post will focus on an insidious reason that ideas are thrown beyond the wall: the timeframe and study size required to test them are unachievable.
Lung-protective ventilation is often considered a simple truth when managing critical care patients on mechanical ventilation. Despite this sense of certainty, the knowledge of exactly how and when to perform such ventilatory strategies is incomplete. The recently published PReVENT adds yet more uncertainty to the true efficacy of low tidal volume ventilation in patients without […]
Drug and Toxin-Induced Hepatic Microvesicular Steatosis From Captain Bligh to Bacillus cereus by Steven Curry, M.D. Department of Medical Toxicology Banner – University Medical Center Phoenix @SteveCurryMD Drug and toxin-induced liver diseases comprise various histologic patterns. A few examples a toxicologist may encounter include perisinusoidal fibrosis with hypervitaminosis A, peliosis hepatis from sex steroids, veno-occlusive […]