Intensivists have long been struggling with the enigma of hemophagocytic lymphohistiocytosis (HLH). For example, this post from 2016 explores the challenge of dissecting HLH away from septic shock. The COVID pandemic has drawn some attention to the topic, although it's not clear to what extent COVID might truly reflect HLH. This chapter attempts to lay out the fundamental groundwork of HLH. Please note that the treatments for adult secondary HLH are not based on any strong evidence, so considerable controversy surrounds the entire topic.
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The IBCC chapter is located 👉 here.
- The podcast & comments are below.
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Very nice overview. Ruxolitinib is used to treat myeloproliferative disorders, not myelodysplastic disorders. It is also used to treat graft vs host disease
The podcast link is nowhere to be found, guys.
My son’s best friend, Christian, just died from HLH this past weekend, I think he had been diagnosed over a year ago. He was 26, a super vibrant, athletic kid, and the whole ordeal was nothing short of horrific. I don’t know his medications but this summer he switched hospitals and I couldn’t believe how his body changed, he didn’t look like the same person. He seemed to be doing better but then he got brain lesions and also went blind in one eye… I just think his body couldn’t fight it any longer. Incredibly tragic how much he suffered… Read more »