PulmCrit (EMCrit)

background Lopinavir/Ritonavir (tradename KALETRA) is a combination of protease inhibitors typically used in HIV, including post-exposure prophylaxis (lopinavir is the actual antiviral agent, with ritonavir functioning to inhibit metabolism of lopinavir, thereby boosting levels of lopinavir).  In vitro, Lopinavir/Ritonavir has activity against SARS-CoV-1 and functions synergistically with ribavirin (the addition of ribavirin increases Lopinavir’s potency […]

Friends, As COVID-19 has exploded, so has the amount of information about COVID-19.  There are currently over 700 publications regarding coronavirus listed in PubMed within the past few months.  More are being released daily.  Many haven’t been catalogued on PubMed yet. This chapter will attempt to synthesize the latest and most important information on COVID-19.  […]

A new study in NEJM compared nonsedation with light sedation in ventilated ICU patients.  This is a follow-up study, aimed at clarifying the results of a prior trial at the same center.  To best understand the current study, we need to start with the first trial… Strom et al. 2010:  A protocol of no sedation […]

The Society of Critical Care Medicine published over 1,800 abstracts to go along with their latest conference. I sifted through them to come up with my favorite 20. Kudos to all the authors on creating diverse and thoughtful work – the future of critical care is indeed bright! The abstracts are divided into six groups: […]

Vasopressor use is an everyday exercise in critical care.  Unfortunately, high-level evidence regarding these agents is often lacking.  Furthermore, patients may react in unique ways.  This chapter attempts to clarify some vasopressor basics, but beware – all of your patients will not read the book. The IBCC chapter is located here. The podcast & comments […]