Thrombotic microangiopathy is a rapidly moving target, which has evolved considerably in just the past few years. Complementopathies (e.g., atypical hemolytic uremic syndrome) probably represent a largely unappreciated, yet critical, dimension of many diseases. Thrombotic thrombocytopenic purpura (TTP) remains an important hematologic emergency that must be promptly recognized. This chapter attempts to disentangle these entities, with a focus on the practical aspects of workup and management.
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[…] Thrombotic microangiopathies – IBCC […]
Is it possible to have MAHA or TMA without schistocytes? Or perhaps it takes time to show up on smear? Here is a case for some context to my question. I recently had a postpartum patient who had emergent CS for abruption, and then developed thrombocytopenia on the 3rd day. Everything else was normal on exam and labs (CMP, Hb, WBC, coags, smear) except a platelet count of 6 and slight lethargy and tachypnea. Imaging was negative for PE or stroke and her echo/EKG was normal. She was admitted to our ICU and less than 24 hrs went into PEA… Read more »