Thrombotic microangiopathy is a rapidly moving target, which has evolved considerably in just the past few years. Complementopathies (e.g., atypical hemolytic uremic syndrome) probably represent a largely unappreciated, yet critical, dimension of many diseases. Thrombotic thrombocytopenic purpura (TTP) remains an important hematologic emergency that must be promptly recognized. This chapter attempts to disentangle these entities, with a focus on the practical aspects of workup and management.
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