IBCC - Thrombotic microangiopathies (TTP, HUS, et al.)

Thrombotic microangiopathy is a rapidly moving target, which has evolved considerably in just the past few years. Complementopathies (e.g., atypical hemolytic uremic syndrome) probably represent a largely unappreciated, yet critical, dimension of many diseases. Thrombotic thrombocytopenic purpura (TTP) remains an important hematologic emergency that must be promptly recognized. This chapter attempts to disentangle these entities, with a focus on the practical aspects of workup and management.