A loading dose may be used to rapidly achieve steady-state pharmacokinetics. For drugs with a long half-life, this accelerates the attainment of therapeutic levels: For most drugs with single-compartment pharmacokinetics, a loading dose may be calculated using the following formula: (discussed further here) The graph below illustrates how this equation works: If (dosing interval)/(half life) […]
EMCrit Wee – Jason Bartos on the Minneapolis ECPR Experience
The best Resus ECMO Lecture EVER!!!!
EMCrit 363 – Retrograde Intubation
Retrograde, in 2023 is basically a backwards way of doing things…
ODR 013 – Should, Must, & Won’t
These 3 words are the path to burnout
EMCrit Shadowboxing Case 6 – A Respiratory Case along with Extra Commentary from Mae West
A pulm-crit shadowboxing case
EMCrit 362 – Jonathan Edlow, Lead Author of GRACE-3, on Dizziness
Dizziness and Vertigo with the lead author of GRACE-3
ODR 012 – Arete, Ancient Wisdom, and Flourishing with Brian Johnson
Brian Johnson talks about his new book, Arete
EMCrit 361 – Life Threatening Tox and Toxicologic Cardiac Arrests from the AHA
AHA Guidelines on Critical Care Toxicology
EMCrit RACC Lit Review – October 2023
All the lit goodness for Oct 2023
PulmCrit blogitorial: Why I don’t believe the AMIKINHAL trial
Some folks on twitter asked my thoughts on AMIKINHAL trial, so I thought I’d jot them here. AMIKINHAL is a multi-center RCT that evaluated the ability of inhaled amikacin to prevent VAP (ventilator-associated pneumonia) among patients who had been intubated for three days. It’s available here at NEJM. It was a positive trial, which is […]
PulmCrit Blogitorial – New IDSA/SCCM guidelines on fever evaluation in ICU
More guidelines! Today we’ll walk through some interesting bits of the new IDSA/SCCM guideline on evaluation of new fever in the adult ICU patient (available free here). how should temperature be evaluated? This is frankly a mess. Bladder catheter or esophageal probe are best, but usually not used. Rectal temperature is 2nd best, but unwieldy […]
EMCrit 360 – A Taxonomy of Key Performance Errors for Emergency Intubation (Primer)
We categorized intubation errors and published a paper about it…
PulmCrit Blogitorial – Why the new brain death guidelines are unacceptable
Hello fellow nerds, let’s take a look at the new American Association of Neurology (AAN) brain death guidelines. Instead of a tweetorial, I’ll jot my thoughts here, so they’re accessible to everyone. Disclaimer: the following discussion applies only to adult medicine. Most of these guidelines are consistent with the 2020 World Brain Death Project, so […]
EMCrit 359 – FoundStab Project – Foundational Stabilization Provisional Guideline for Post-Intubation Sedation
The first version of the first guideline in the foundational stabilization project – post-intubation sedation
ODR 011 – Kettlebells for the Brain – Meditation
A slightly different kind of topic was my inspiration for the John Hinds Keynote at SMACC
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