as of 3 APR 2020
Search Results for: COVID-19
ThinkingCC COVID Respiratory Management Webinar
cutting edge info on COVID19 management
EMCrit 270 – Airway Pressure Release Ventilation (APRV) Time-Controlled Adaptive Ventilation
A Primer on APRV – TCAV, perhaps the mode of choice for COVID19
PulmCrit- American research infrastructure is killing us: The misbegotten battle between the ivory tower academics and the rogue cowboys
the battle between the ivory tower academics vs. the rogue cowboys An internecine war is brewing about the treatment of COVID-19. You can hardly open up a journal or look at social media without getting caught in the cross-fire. The cause of the schism is pretty simple. There are no proven treatments for COVID-19. Based […]
PulmCrit – Preliminary report on NIAID trial of remdesivir (ACTT-1)
The preliminary report of the Adaptive COVID-19 Treatment Trial (ACTT-1), a multi-center, placebo-controlled RCT on remdesivir is here!1 The one we’ve all been waiting for! Patients Patients were recruited from 60 sites in several countries. Inclusion criteria were patients who were hospitalized due to COVID-19 with evidence of lower respiratory tract infection, defined in terms […]
EMCrit Guest Post – COVID – The anticipated difficult and protected airway: A case study
Case report of a COVID airway with discussion and checklists
PulmCrit – RECOVERY confirms benefit of toci combined with dexamethasone
The RECOVERY trial just released a preprint demonstrating benefit from tocilizumab in COVID-19. As with the prior RECOVERY studies, this is a multicenter, open-label, pragmatic trial. A robust mortality benefit was detected (the fragility index calculates to 17, which isn’t too shabby). Several important secondary endpoints were positive as well (e.g., reduced intubation rate, reduced […]
PulmCrit – Oscar awards for the best COVID prognostic models
We are continually tasked with triaging COVID patients, a situation which will become more complex as the numbers continue to rise. This involves making educated guesses about which patients are most likely to deteriorate, and which patients may benefit most from critical care. That’s enormously difficult. At this point, we’re quite familiar with individual risk […]
COVID Airway Management Thoughts
additional COVID airway management thoughts
EM Nerd-The Case of the Partial Cohort
The global suffering wrought by SARS-CoV-2 pandemic is undeniable. But so is the ferocity with which the world has pursued a cure. And while some potential remedies have held more promise than others, the enthusiasm supporting these novel treatments often outpaced their evidentiary support. In fact, none have demonstrated efficacy backed by high quality randomized […]
PulmCrit – Dexamethasone & COVID – a study in immunopathology, evidence-based medicine, and ourselves
Early in the COVID epidemic, it became clear that the virus often causes a cytokine storm, leading to immunopathological organ damage. The first major study to suggest benefit from steroid in COVID was a retrospective study by Wang et al. released in early March, which found reduced mortality among COVID patients with ARDS who were […]
PulmCrit – Want to help stop COVID? Be quiet.
The closed mouth catches no flies Benjamin Franklin, Poor Richard’s Almanac, 1742 We’re hopefully nearing the end of the COVID pandemic, with vaccines coming soon. Unfortunately, vaccines won’t be able to bail us out this winter. Neither will fancy designer pharmaceuticals. The main interventions necessary to keep us safe for now are basic public health […]
Neurological complications of COVID
CONTENTS Limitations of this chapter Brief word on pathogenesis General clinical principles Encephalopathy Diffuse leukoencephalopathy with diffusion restriction Acute necrotizing encephalopathy (ANE) Mild encephalopathy with reversible splenial lesion (MERS) Acute disseminated encephalomyelitis (ADEM) & Acute hemorrhagic leukoencephalitis (AHLE) Myelitis Autoimmune encephalitis Posterior reversible encephalopathy syndrome (PRES) Stroke Acute ischemic stroke Intracranial hemorrhage & microbleeds Cerebral […]
PulmCrit- RCTs don’t justify using convalescent plasma or antibody cocktails
Passive immunity refers to the infusion of antibodies (either polyclonal antibodies in the form of convalescent plasma, or engineered monoclonal antibodies). The goal is to neutralize viral particles, reduce viral replication, and thereby improve clinical outcomes. This is a promising theory, but it requires evidentiary support in the form of randomized controlled trials. So far, […]
PulmCrit Wee – Follow-up Bamlanivimab study unmasks statistical chicanery
Whether or not you have any interest in bamlanivimab, you should read this post as an amusing example of shoddy statistics being published in top journals. background & general landscape of the two trials The BLAZE-1 trial involved randomizing patients within three days of testing positive for COVID-19 to one of four arms: placebo, 700 […]
- « Previous Page
- 1
- 2
- 3
- 4
- 5
- …
- 8
- Next Page »