Valproic acid poisoning is fortunately uncommon. However, this is a potentially lethal and rather complex intoxication. Management spans the gamut from decontamination and dialysis, to various metabolic manipulations. With an aggressive and organized approach, most patients will do extremely well.
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Josh is the creator of PulmCrit.org. He is an associate professor of Pulmonary and Critical Care Medicine at the University of Vermont.
Latest posts by Josh Farkas (see all)
- IBCC chapter & cast – Stress hyperglycemia in the ICU - October 19, 2020
- IBCC chapter & cast – Wernicke encephalopathy - October 14, 2020
- IBCC chapter & cast – Valproic Acid Intoxication - October 5, 2020
Besides of valproic acid level, What lab should you order in a patient with new onset altered mental status who is taking Valproate? Ding…..Ding……Ding ….an ammonia level…. This is perhaps one of my favorite teaching points for residents. Followed by what do u give if ammonia is elevated, no cirrhosis history, and they are on valproate…..but L- Carnitine of course. However, if somebody is altered on Depakote order an ammonia level and a valproic acid level together. Do not wait and then reflexively ordered the ammonia level if the valproic acid level.elevated.in a patient on valproic acid with altered mental… Read more »
[…] ,Valproic acid poisoning is fortunately uncommon. However, this is a potentially lethal and rather complex intoxication. Management spans the gamut from decontamination and dialysis, to various metabolic manipulations. With an aggressive and organized approach, most patients will do extremely well. The IBCC chapter is located here. The podcast & comments are below. Follow us EMCrit Project by Josh Farkas.,Read More […]