In episode 130 of the podcast and in many subsequent discussions, I have advocated for femoral-artery-monitoring during cardiac arrest to allow titrated use of vasopressors. Many of my colleagues in the advanced resuscitation community have a similar practice. In 2013, the AHA has released an advanced practice guideline recommending the same practice.1
But…
What if the diastolic blood pressure number shown on the monitor is the WRONG PRESSURE. That is the contention of our guest today:
Per-Olav Berve is a Norwegian anaesthesiologist who works for the Oslo air ambulance and in-hospital at the Oslo University Hospital. He is currently wrapping up a PhD on CPR physiology, focusing on multimodal monitoring. His main project is a OHCA study on mechanical active compression-decompression CPR. (Bio from scanFOAM).It seems the machine picks the DBP that is the lowest point between systoles. This works well with waveforms generated by the normal cardiac compression. During CPR, however the lowest point (decompression phase nadir) actually represents the reformation of the aortic outflow tract after it has been compressed. This generates a brief negative pressure which can give extremely low pressures. If you use this as your DBP you will be steered in exactly the wrong direction–the better the cpr and the more pronounced the vascular tone, the lower this number will be.
In the arterial wave form image above, Point A is a DBP of zero. This is the number that will appear on the monitor; this number can actually be negative. In the past, I would be rezeroing the transducer thinking it must be in error. And when I spoke about refractory vasoplegia, it was because of this number. What we need to be looking at is Point B, the point just before the systolic upstroke–this is the true DBP to titrate your vasopressors according to PO. The better the CPR and the higher the vasomotor tone, the lower Point A and the higher Point B will be. So as we are doing better, we will see lower and lower DBPs if we go by the displayed numbers.
Here is a normal waveform from an actual beating heart as contrast:
Solutions
You must visualize the waveform rather than looking at the computer-generated DBP
- Change displayed waveforms to 10 sec. if possible
- Auto-Wave (match the top and bottom of the scale to the actual waveform parameters) to make the waveforms as big as possible
- If your machine has a line that can be set to a pressure, put it at 40 mm Hg and then just look to see if the beginning of the systolic upstroke is above this line
The Full Lecture from the Big Sick
ScanFOAM has an amazing post with PO's full lecture, slides, and all the references from the lecture.
The Paradis et al. Papers
- 1989 Paper2
- 1990 Paper3
Superimposed Aortic and Right Atrial Waveforms
Note that the CVP and arterial waveforms look almost identical–you cannot differentiate arterial versus venous placement with waveforms alone.
The period of diastolic filling in the late decompression phase is shown below:
Identical Waves with the AutoPulse
Additional Information
- Review Article on where to measure DBP during CPR4
- Understanding Arterial Pressure5
- Experimental Simultaneous Waveforms on Swine6
- Case Report7
We screw up ETCO2 as well
- More from PO on this topic coming soon…
Now on to the Podcast…
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Scott Weingart
Latest posts by Scott Weingart (see all)
- EMCrit Podcast 244 – Incredibly Important Wrinkles to Titrated Vasopressors during CPR in Cardiac Arrest - April 15, 2019
- EMCrit Podcast 243 – The COACT Trial on Early vs. Delayed Cath after Cardiac Arrest without STEMI - March 31, 2019
- EMCrit Podcast 242 – ED Nephrology with Joel Topf aka KidneyBoy - March 9, 2019
After a few moments of listening I was biting my thumbs for not seeing this sooner. I had a few cases with arrest fem lines – which have become routine at our shop – where I had negative diastolics and clearly mistakenly blamed the line setup.
This is really important stuff, and setting the line at somewhere between 30 and 40 to make sure the pre-systolic plateau can be estimated at a glance is the way I’ll be going from now.
Of course I think it is important not to consider this as an “artefact” as it isn’t at all. In that early diastole, as discussed, it is unlikely any coronary perfusion takes place. It would be interesting to see if TEE guided correct placement – a la Teran – impacts this by a more concentrated LV pressure and perhaps less on the ascending aorta – likely reason for the rebond, remembering that in normal physiology this vessel never “collapses.”
Great, great post Scott, and fantastic Big Sick lecture by PO Berve!
yes, super curious to see this as well. Felipe is already v. involved in this stuff and has been working with Paradis, so I think we will have these answers.
[…] Weingart recently did an emcrit podcast with PO specifically on this topic of diastolic pressure targets during CPR. A lot more to be learned there […]
Scott,
Thanks for the thought provoking podcast.
Really we should be looking at the area under the curve, not diastolic nadir. Coronary perfusion is proportional to the pressure difference between that in the aorta during diastole and ventricular diastolic pressure. This applies for all of diastole, not just the nadir. The nadir is a convenient place to look, but oversimplifies this physiologic relationship. What we need is a monitor that splits the mean arterial pressure (MAP) measurement (which is calculated based on area under the curve) into two parameters: systolic mean pressure and diastolic mean pressure. With the diastolic mean pressure value, we can then set a more accurate goal that includes all of the peaks and troughs in pressure during cpr.
Hi Ari, PO here jumping in on this one:) Thanks for this interesting comment. I just need to point out that the term “nadir” in the text above refers to the lowest point on the curve – the one chosen by all monitors I know of to represent diastolic pressure – and our main issue is that this does not reflect changes in peripheral resistance properly. I guess you are referring to the end decompression point in your comment. In regards to your main argument – the area between the curves theory : the Oslo group (Sunde et al (including my PhD advisor Dr Lars Wik) actually tested this in the late 90ies in several pig studies (1) – and it worked great. An algorithm able to identify these pressures and properly calculate the relevant area would be of great interest. However, the issue now is that no such algorithm exists – and especially not for use in human clinical settings. You would also need a properly placed CVK, dual pressure transducer and a some more stuff that might be a bit more time consuming to set up. Finally, we actually do not if the negative spike, or its impact… Read more »
To elaborate a bit further on the issue with the two MAP strategy( aka: compression phase MAP and decompression phase MAP).
This is a doable (semi-manual) job in the post hoc data analysis of most animal trials (with typically 10-20 animals and treatment times of 10-20 minutes). Real-time analysis and / or validation in bigger human studies would demand an automatic algorithm like the one you suggests. This is similar to i.e the PICCO or arterial-line based CO tools that are used for spontaneous circulation. However, the dynamic curve-forms during CPR creates som challenges.
The difficult parts are 1) to make the algorithm choose the correct upstrokes/downstrokes to work on and 2) to make the algorithm able to handle all cannulation sites.
As you probably are aware of, curve profiles and timing of curve profile changes varies to a certain degree with cannulation site, and readings from all sites varies dynamically within a treatment period. Synchronisation to ie. a chest compression device and /or transthoracic impedance signals is the obvious answer, but without an obvious solution so far.
Very interesting, everything make sense.
I would like someone to point out on the “Here is a normal waveform from an actual beating heart as contrast:” and label about where we are supposed to be reading the DBP. While the labeled picture above this picture is a little helpful. . .that’s not what we are using in practice. On the real monitor wave provided, it looks like a smooth ascending curve, straight from the lowest point, so the DBP and the “true DBP” that you are wanting us to use seem to be one in the same.
Gabe
it is the same point on the normal waveform above–the systolic upstroke. the difference is that the machine will correctly use that point, because it is the lowest point between systoles.