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You are here: Home / EMCrit-RACC / EMCrit Podcast 244 – Incredibly Important Wrinkles to Titrated Vasopressors during CPR in Cardiac Arrest

EMCrit Podcast 244 – Incredibly Important Wrinkles to Titrated Vasopressors during CPR in Cardiac Arrest

April 15, 2019 by Scott Weingart 18 Comments

In episode 130 of the podcast and in many subsequent discussions, I have advocated for femoral-artery-monitoring during cardiac arrest to allow titrated use of vasopressors. Many of my colleagues in the advanced resuscitation community have a similar practice. In 2013, the AHA has released an advanced practice guideline recommending the same practice.1

But…

What if the diastolic blood pressure number shown on the monitor is the WRONG PRESSURE. That is the contention of our guest today:

Today's Guest
Per-Olav Berve is a Norwegian anaesthesiologist who works for the Oslo air ambulance and in-hospital at the Oslo University Hospital. He is currently wrapping up a PhD on CPR physiology, focusing on multimodal monitoring. His main project is a OHCA study on mechanical active compression-decompression CPR. (Bio from scanFOAM).

It seems the machine picks the DBP that is the lowest point between systoles. This works well with waveforms generated by the normal cardiac compression. During CPR, however the lowest point (decompression phase nadir) actually represents the reformation of the aortic outflow tract after it has been compressed. This generates a brief negative pressure which can give extremely low pressures. If you use this as your DBP you will be steered in exactly the wrong direction–the better the cpr and the more pronounced the vascular tone, the lower this number will be.

Image from PO Berve

In the arterial wave form image above, Point A is a DBP of zero. This is the number that will appear on the monitor; this number can actually be negative. In the past, I would be rezeroing the transducer thinking it must be in error. And when I spoke about refractory vasoplegia, it was because of this number. What we need to be looking at is Point B, the point just before the systolic upstroke–this is the true DBP to titrate your vasopressors according to PO. The better the CPR and the higher the vasomotor tone, the lower Point A and the higher Point B will be. So as we are doing better, we will see lower and lower DBPs if we go by the displayed numbers.

Here is a normal waveform from an actual beating heart as contrast:

Solutions

You must visualize the waveform rather than looking at the computer-generated DBP

  • Change displayed waveforms to 10 sec. if possible
  • Auto-Wave (match the top and bottom of the scale to the actual waveform parameters) to make the waveforms as big as possible
  • If your machine has a line that can be set to a pressure, put it at 40 mm Hg and then just look to see if the beginning of the systolic upstroke is above this line

The Full Lecture from the Big Sick

ScanFOAM has an amazing post with PO's full lecture, slides, and all the references from the lecture.

  • PO Berve on Waveforms during Cardiac Arrest from scanFOAM

The Paradis et al. Papers

  • 1989 Paper2
  • 1990 Paper3

Superimposed Aortic and Right Atrial Waveforms

from Paradis et al. 1989

Note that the CVP and arterial waveforms look almost identical–you cannot differentiate arterial versus venous placement with waveforms alone.

The period of diastolic filling in the late decompression phase is shown below:

from Larsen et al. 2010

Identical Waves with the AutoPulse

from 10.1007/s00134-010-1784-x

Additional Information

  • Review Article on where to measure DBP during CPR4
  • Understanding Arterial Pressure5
  • Experimental Simultaneous Waveforms on Swine6
  • Case Report7

We screw up ETCO2 as well

  • More from PO on this topic coming soon…

Now on to the Podcast…

http://media.blubrry.com/emcrit/p/traffic.libsyn.com/emcrit/EMCrit-Podcast-20180413-244-Wrinkle-DBP-CPR2.mp3

Podcast: Play in new window | Download (Duration: 26:21 — 24.5MB) | Embed

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1.
Meaney PA, Bobrow BJ, Mancini ME, et al. Cardiopulmonary Resuscitation Quality: Improving Cardiac Resuscitation Outcomes Both Inside and Outside the Hospital. Circulation. 2013;128(4):417-435. doi:10.1161/cir.0b013e31829d8654
2.
Paradis N, Martin G, Goetting M, et al. Simultaneous aortic, jugular bulb, and right atrial pressures during cardiopulmonary resuscitation in humans. Insights into mechanisms. Circulation. 1989;80(2):361-368. [PubMed]
3.
Paradis N, Martin G, Rivers E, et al. Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation. JAMA. 1990;263(8):1106-1113. [PubMed]
4.
Otlewski M, Geddes L, Pargett M, Babbs C. Methods for calculating coronary perfusion pressure during CPR. Cardiovasc Eng. 2009;9(3):98-103. [PubMed]
5.
Morelli A, De B. The ten principles behind arterial pressure. Intensive Care Med. 2018;44(6):911-914. [PubMed]
6.
Sunde K, Wik L, Naess P, Ilebekk A, Nicolaysen G, Steen P. Effect of different compression–decompression cycles on haemodynamics during ACD-CPR in pigs. Resuscitation. 1998;36(2):123-131. [PubMed]
7.
Larsen A, Hjørnevik A, Bonarjee V, Barvik S, Melberg T, Nilsen D. Coronary blood flow and perfusion pressure during coronary angiography in patients with ongoing mechanical chest compression: a report on 6 cases. Resuscitation. 2010;81(4):493-497. [PubMed]
  • Author
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Scott Weingart

An ED Intensivist from NY. No conflicts of interest (coi).

Latest posts by Scott Weingart (see all)

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  • Letter to the Editor – High-Sensitivity Troponin is not a Myth, and “Myth-busting” is often another Myth to be Busted - November 10, 2019

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Filed Under: EMCrit-RACC Tagged With: featured

Cite this post as:

Scott Weingart. EMCrit Podcast 244 – Incredibly Important Wrinkles to Titrated Vasopressors during CPR in Cardiac Arrest. EMCrit Blog. Published on April 15, 2019. Accessed on December 11th 2019. Available at [https://emcrit.org/emcrit/dbp-cpr/ ].

Financial Disclosures

Unless otherwise noted at the top of the post, the speaker(s) and related parties have no relevant financial disclosures.

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Philippe Rola
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Philippe Rola

After a few moments of listening I was biting my thumbs for not seeing this sooner. I had a few cases with arrest fem lines – which have become routine at our shop – where I had negative diastolics and clearly mistakenly blamed the line setup.

This is really important stuff, and setting the line at somewhere between 30 and 40 to make sure the pre-systolic plateau can be estimated at a glance is the way I’ll be going from now.

Of course I think it is important not to consider this as an “artefact” as it isn’t at all. In that early diastole, as discussed, it is unlikely any coronary perfusion takes place. It would be interesting to see if TEE guided correct placement – a la Teran – impacts this by a more concentrated LV pressure and perhaps less on the ascending aorta – likely reason for the rebond, remembering that in normal physiology this vessel never “collapses.”

Great, great post Scott, and fantastic Big Sick lecture by PO Berve!

What's Your Job?
ICU doc
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7 months ago
Scott Weingart
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Scott Weingart

yes, super curious to see this as well. Felipe is already v. involved in this stuff and has been working with Paradis, so I think we will have these answers.

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emcrit
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7 months ago
Per-Olav Berve
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Per-Olav Berve

Hi! I agree – it is not an artifact – these spikes occur even with membrane catheters used in the research setting. Therefore, the assumption made in the Paradis ’90 paper that the dynamic trace in the decompression phase (they use the term relaxation phase) is due to movement of the fluid filled long catheters is likely not correct. Importantly, the spikes tend to be more evident with good peripheral resistance and be more dynamic or even disappear if a solid ROSC is established during compressions. Thus, they may be telling us important stuff about how things are going before ROSC, and not merely be useful as an indicator that ROSC already has occurred (a lot of studies establish fairly obvious findings that things get better after ROSC – but are truly unhelpful in telling us how to get ROSC in the first place) Further on, even if some studies suggest shorts burst of retrograde carotid flow occur during CPR, we must remember that arterial pressure is a complex physical phenomenon that is poorly related to flow – and especially coronary flow in early decompression phase when the aortic valve is closing in an expanding LVOT. I have seen some… Read more »

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Consultant PHEM anaesthesiologist
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7 months ago
Joe Bellezzo
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Joe Bellezzo

Incredible. FINALLY this makes sense. And I feel like a complete moron. Honestly I never even looked at the waveform…just that diastolic pressure number. Like Scott, I just assumed that number was going down due to vasoplegia and nearing death. This is a HUGE thing for those of us who are doing ECPR because it appears I’m overdosing my vasopressors. Now, once I decide I’m putting someone on ECMO during CPR I do not give any more pressor until after they are on-pump. But based on this, I’ve been giving too much vasopressor early on, during traditional CPR. Gosh I cannot help but wonder whether some of our ECPR cases that went on pump quickly, yet ended up with ‘anoxic brain injury’, were caused by epi OD because I thought the DBO was really ~2!!!

This is a game changer for me.

thank you to PO for pushing this to us all.

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Emergency Physician
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7 months ago
Per-Olav Berve
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Per-Olav Berve

Hi Joe! Great to hear this from you! I do of course agree with you that having the correct decompression phase pressure to work with is of immense value when you are trying to decide if cerebral perfusion pressures are adequate for brain survival. To be more precise: as you know, for cerebral perfusion it is MAP that drives blood up to the brain. However, the monitors MAP calculations by means of whatever formula it use (i.e. SBP+2xDBP/3) can be horribly wrong depending on which value the monitor use as DBP. So – when I calculate MAP in this situation I just approximate it by the formula: (SBP+end decompression pressure)/2. (*see footnote) Oslo HEMS bring in aprox 20 cases for ECPR (directly to angiolab) each year with mean dispatch to angiolab times around 40-50 minutes. We place IBP lines in some of these cases (if logistically possible) and find it very helpful to guide resuscitation. Anecdotally, a MAP of 70, calculated by this simplified algorithm has been adequate at several occasions – although a lot more research is needed to identify the correct “CPR MAP” for adequate and possibly ideal cerebral perfusion. *Remember: LUCAS do 50/50 duty cycle so the… Read more »

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Consultant PHEM anaesthesiologist
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7 months ago
trackback
Hemodynamics during mechanical CPR - scanFOAM

[…] Weingart recently did an emcrit podcast with PO specifically on this topic of diastolic pressure targets during CPR. A lot more to be learned there […]

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7 months ago
Ari Daube
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Ari Daube

Scott,

Thanks for the thought provoking podcast.

Really we should be looking at the area under the curve, not diastolic nadir. Coronary perfusion is proportional to the pressure difference between that in the aorta during diastole and ventricular diastolic pressure. This applies for all of diastole, not just the nadir. The nadir is a convenient place to look, but oversimplifies this physiologic relationship. What we need is a monitor that splits the mean arterial pressure (MAP) measurement (which is calculated based on area under the curve) into two parameters: systolic mean pressure and diastolic mean pressure. With the diastolic mean pressure value, we can then set a more accurate goal that includes all of the peaks and troughs in pressure during cpr.

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PICU Attending
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7 months ago
PO Berve
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PO Berve

Hi Ari, PO here jumping in on this one:) Thanks for this interesting comment. I just need to point out that the term “nadir” in the text above refers to the lowest point on the curve – the one chosen by all monitors I know of to represent diastolic pressure – and our main issue is that this does not reflect changes in peripheral resistance properly. I guess you are referring to the end decompression point in your comment. In regards to your main argument – the area between the curves theory : the Oslo group (Sunde et al (including my PhD advisor Dr Lars Wik) actually tested this in the late 90ies in several pig studies (1) – and it worked great. An algorithm able to identify these pressures and properly calculate the relevant area would be of great interest. However, the issue now is that no such algorithm exists – and especially not for use in human clinical settings. You would also need a properly placed CVK, dual pressure transducer and a some more stuff that might be a bit more time consuming to set up. Finally, we actually do not if the negative spike, or its impact… Read more »

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7 months ago
Per-Olav Berve
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Per-Olav Berve

To elaborate a bit further on the issue with the two MAP strategy( aka: compression phase MAP and decompression phase MAP).
This is a doable (semi-manual) job in the post hoc data analysis of most animal trials (with typically 10-20 animals and treatment times of 10-20 minutes). Real-time analysis and / or validation in bigger human studies would demand an automatic algorithm like the one you suggests. This is similar to i.e the PICCO or arterial-line based CO tools that are used for spontaneous circulation. However, the dynamic curve-forms during CPR creates som challenges.

The difficult parts are 1) to make the algorithm choose the correct upstrokes/downstrokes to work on and 2) to make the algorithm able to handle all cannulation sites.

As you probably are aware of, curve profiles and timing of curve profile changes varies to a certain degree with cannulation site, and readings from all sites varies dynamically within a treatment period. Synchronisation to ie. a chest compression device and /or transthoracic impedance signals is the obvious answer, but without an obvious solution so far.

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Consultant PHEM anaesthesiologist
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7 months ago
Gabe
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Gabe

Very interesting, everything make sense.

I would like someone to point out on the “Here is a normal waveform from an actual beating heart as contrast:” and label about where we are supposed to be reading the DBP. While the labeled picture above this picture is a little helpful. . .that’s not what we are using in practice. On the real monitor wave provided, it looks like a smooth ascending curve, straight from the lowest point, so the DBP and the “true DBP” that you are wanting us to use seem to be one in the same.

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ICU RN
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7 months ago
Scott Weingart
Author
Scott Weingart

Gabe
it is the same point on the normal waveform above–the systolic upstroke. the difference is that the machine will correctly use that point, because it is the lowest point between systoles.

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emcrit
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7 months ago
Alexander Dejaco
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Alexander Dejaco

Hello PO Hello Scott Thanks for this enlightening Podcast! > The difficult parts are 1) to make the algorithm choose the correct upstrokes/downstrokes to work on and 2) to make the algorithm able to handle all cannulation sites Comparing to other algorithmic challenges in medical engineering it is not such a difficult task. I think I could even program a phone app that you coul hold in front of an arterial Signal to calculate the appropriate diastolic value and/or an area under the curve. But ist not worth it, I think, since as scott mentioned a lot of machines allow you to put a horizontal Cursor and thats fine. Of Course an algorithm might not always be perfect depending on the site and artefacts. But the algorithm could f.i. put markers on the line to confirm where it measures what so that a user can get Feedback if ist an accurate reading or not. (I was an engineer before I went into medicine/anaesthesia). I have another question: Are we sure that in cardiac arrest the myocard is only perfused in diastoly? Ist clear in a spontaneously beating heart that it cant perfuse itselfe while the myocard contracts, but in a… Read more »

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7 months ago
PO Berve
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PO Berve

Hi Alexander!
You are right – when we analyse pressures on each side of the coronaries – the readings will often indicate a possibility for perfusion during (part of) the compression phase. However, we actually do not know if it is the case as no study I know of has looked into this specific question in humans. There are animal studies suggesting even retrograde flow – and the mechanism would be that the external squeeze on the heart muscle hinders forward flow and even push blood backwards. I would guess that this is a very dynamic situation, but have anecdotally seen a patient getting ROSC after surgeons thumb have been moved away from LAD during direct open CPR… Point is until we get the in vivo contrast study during cath-lab CPR – we don’t know.

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Consultant HEMS anaesthesiologist
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7 months ago
Alexander Dejaco
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Alexander Dejaco

Thanks for your reply. Indeed, very dynamic situation for sure. So probably for now best is to use the estimated ‘real’ diastolic measurement..

Best wishes,
Alex

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anesthetist
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7 months ago
Jesper Fjølner
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Jesper Fjølner

Super interesting!. The arterical curves from Larsen (2010), optained under LUCAS-1 massage, do not display the same deep downward deflection towards zero-pressure. Why is that? Less suction form LUCAS-1? Due to values measured at the aortic root in the Larsen paper?

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7 months ago
PO Berve
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PO Berve

Hi Jesper!
The example in Larsen is collected at the coronary ostia (thus very proximal aorta) – these are the lowest lines presented in the figure. They actually show such a negative spike on both atrial and arterial side. the have marked out how they calculated perfusion pressures and of note is the simultaneous end decompression phase pressures that correlate well with perfusion. for further reading I recommend the excellent PhD thesis by Henrik Wagner – showing flow patterns as well. I am uncertain wether active decompression actually affects this as I have seen very low readings with standard LUCAS as well.

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Consultant HEMS anaesthesiologist
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7 months ago
Dean Burns
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Dean Burns

Hi Scott & Per

I hope I followed this. If so, if you put your line across & your systolic inflection point is above 40mmHg, am I right in thinking that there is no additional gain in pushing more epinephrine for your patient?

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Emergency Phyisician/Intensivist
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2 months ago
Scott Weingart
Author
Scott Weingart

Dean, if the DIASTOLIC takeooff is above the line, not the systolic.

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emcrit
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2 months ago

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