Anion gap metabolic acidosis is generally the most worrisome pH abnormality. Many of the causes of anion gap elevation reflect a life-threatening problem (e.g. hyperlactatemia, shock, diabetic ketoacidosis, toxic alcohol poisoning). Particularly if the anion gap elevation is a new finding, this mandates immediate investigation (and sometimes, simultaneous resuscitation). This chapter explores the causes of anion gap elevation and a strategy for investigation.
The IBCC chapter is located here.
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