Differentiation of bradykinin - vs histamine - mediated angioedema - Internet Book of Critical Care, by @PulmCrit Type of angioedema is clear Type of angioedema remains unclear Treat Consider historical & clinical features in above tabl e - Likely bradykinin - mediated - Initiate anti - bradykinin therapies - Likely histamine - mediated - Continue therapy Trial of immediate & aggressive therapies for histamine - mediated angioedema (steroid, anti - histamine, +/ - epinephrine) Clinical improvement No improvement