medical therapy for bradykinin - induced angioedema - Internet Book of Critical Care, by @PulmCrit Moderate to severe bradykinin - induced angioedema ACEi - induced Not ACEi - induced Immediate treatment: 1 gram tranexamic acid IV Consider fresh frozen plasma (2 Units) May repeat x1 if inadequate response Consider C1 - inhibitor concentrate (especially if known C1 - inhibitor deficiency) If persistent, may consider addition of C1 - inhibitor