Addiction beyond dopamine with Dr. Andy Chambers
Join Dan (@drusyniak) &howard (@heshiegreshie) as they explore the neurobehavioral underpinnings of addiction. Learn about the Google Maps of the motivational system of the brain and gain insight into why psychiatric patients and adolescents are such vulnerable populations. And make sure that you check out Dr. Andy Chambers book, The 2 x 4 Model: A Neuroscience-Based Blueprint for the Modern Integrated Addiction and Mental Health Treatment System.
Here is a link to the Robinson and Berridge article from 1993 cited by Dr. Chambers, The Neural Basis of Drug Craving: An Incentive-Sensitization Theory of Addiction.
Who is your favorite addicted character in pop culture?
- Dr. Rick Sanchez
- Dr. Gregory House
- Jessie Pinkman
- Jackie Peyton, RN
- Tyrone Biggums (NSFW)
- Robert Palmer
We are discontinuing the @dantastictox Twitter handle, tiki focus our social media efforts on the larger endeavor at The Tox & The Hound. As always, we are looking for feedback – comments, questions, suggestions, recipes, etc. Let us know. Reach us at @toxandhound. We want to hear from you!
Thank you to our house band Pretty Simple Duo (@prettysimpleduo), our announcer Josh Shelov (@shelovj) and Witness Protection Products.
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Stay Healthy, True Believers!
Highway by Cosmic Timetraveler
- Tox and Hound – Love and Half-Life* - February 26, 2020
- Tox and Hound – One Therapy To Rule Them All? Sugar vs Squeeze in Cardiotoxic Poisoning - February 18, 2020
- Tox & Hound – A Toxicological Brain Teaser. The Complexities of Valproic Acid Metabolism. - February 4, 2020
I appreciated the concepts of ‘varied vulnerability across patients’ and the ‘road map’ theory of addiction. Although now retired, I follow the trends and have misgivings about new, well-intentioned but misguided approaches utilizing alternatives like ketamine and IV acetominophen in post-op patients to ostensibly avoid later addiction., I agree that pop-up charlatan ‘treatment’ clinics are seemingly next door to every grocery store across America and/or people like Miriam and Sheldon Adelson’s ‘rehab’ clinics cater to moneyed addicts on the West Coast. This makes me recall Robert Downey Jr., saying (after he ultimately detoxed after multiple near death heroin overdoses, that the problem was NEVER ‘getting clean’; but in NOT starting up drug use again! I suspect the answer lies in that realm of ‘not starting again’ but it’s so multi-faceted (and EXPENSIVE) that no single discipline can mount an effective response. I am saddened to hear you both say that we (medical community) caused this problem although I know I had my own role to play in rx-ing opiates at bit freely, when it was not unusual to do so. I also recall an inservice in the late 90s hearing the anesthesiologist advising us to rx fentanyl patches ‘for pain’… Read more »
I do not see how accepting some blame on behalf of providers is inappropriate, especially as there is plenty of evidence of some physicians most definitely taking advantage of liberal opioid prescription. However, I agree that the arrow definitely points stronger in another direction..
[…] Dantastic Mr. Toxic and Howard podcast tackle the theories surrounding how addiction affects the brain. The motivational system and at-risk populations are discussed as well as several pop-culture […]