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You are here: Home / Archives for sepsis

EM Nerd: The Case of the Sour Remedy Continues

January 20, 2020 by Rory Spiegel 7 Comments

The use of IV vitamin C as a therapeutic agent in sepsis has caught the hearts and minds of emergency medicine and critical care clinicians. Since the publication of a small single center before and after study by Marik et al in 2017 (1), we have spent countless hours screaming into the void that is […]

Tox and Hound – Color Me Blue

October 21, 2019 by Tox & Hound 1 Comment

by Christine Murphy Alternative Uses for Methylene Blue I like finding alternative uses for existing antidotes. Antidote research is very limited – let’s be honest, there isn’t a huge market out there for most antidotes. So, anytime an existing antidote’s use can be expanded to other indications, I think that is a win. Methylene blue […]

EM Nerd-The Case of the Hurried Objective

October 8, 2019 by Rory Spiegel 2 Comments

In 2015, Centers for Medicare & Medicaid (CMS) published their sepsis core measure (SEP-1). This represented a nationally mandated sepsis management strategy presented in the form of a 3 and 6-hour bundle. Since its publication, the Surviving Sepsis Campaign (SSC) released their own 1-hour bundle (1), adding even more urgency to an already frenetic effort […]

EM Nerd-The Case of the Microscopic Imperative

September 19, 2019 by Rory Spiegel 2 Comments

In the management of sepsis, the acquisition of blood cultures prior to the administration of antibiotics has been a long-held dictum, even before it gained the regulatory support due to its place in the SEP-1 3-hour bundle. But how much is lost if we defer the acquisition of blood cultures until after the administration of […]

EM Nerd-The Case of the Deceitful Lantern

February 19, 2019 by Rory Spiegel 9 Comments

Since the publication of the sepsis trilogy, PROMISE, ARISE, and PROCESSĀ 1,2,3, abruptly displaced early goal directed therapy (EGDT) as the cornerstone of sepsis management, we have been searching to fill the therapeutic vacuum its sudden departure left behind. The Center for Medicare and Medicaid Services (CMS) and the Surviving Sepsis Campaign (SSC) have both rushed […]

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