Sedation is one of the details of ICU care which seems unimportant…  until it's not.  Over the past decade we've seen a burgeoning repertoire of agents used for sedation and agitated delirium.  Unfortunately, the number of medications has out-stripped available Level-I evidence regarding how exactly to use them.  This chapter attempts to create a framework for the selection and use of various agents.  Looming drug shortages due to COVID-19 may force us to push the envelope, by using different agents in ways which we haven't previously.

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Josh Farkas
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