Janus kinases (JAKs) are named after Janus, the Greek god of beginnings, gates, transitions, and duality.  They’re named after Janus because they contain a mirror-image structural element.  However, given their role within the immune system as a multi-functional gateway for cytokine systems, the name seems apt.  The cytokine storm induced by COVID-19 has received considerable … Continue reading PulmCrit Wee – Multicenter RCT evaluating ruxolitinib (a JAK inhibitor) for COVID-19