Patients carrying the label of “penicillin allergy” or “cephalosporin allergy” are likely to receive suboptimal antibiotics, leading to decreased efficacy and increased toxicity. This is a major problem, as these labels are common.
Emerging evidence shows that there is no such thing as a “penicillin allergy” or “cephalosporin allergy.” Instead, cross-allergic reactions are restricted to much smaller groups of antibiotics that share greater structural similarity. This opens the door to using beta-lactam antibiotics safely in patients who have had an allergic reaction to one or more of these drugs.
The IBCC chapter is located here.
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