Blockade of the fast cardiac sodium channels is an important component of cardiotoxicity due to many intoxicants. Historically the most common cause of sodium channel blockade has been tricyclic antidepressant poisoning, but a wide variety of xenobiotics can affect the sodium channels. Fortunately, close attention to the EKG may be sufficient to reach an accurate diagnosis of sodium channel blockade (regardless of the agent involved).
The IBCC chapter is located 👉 here.
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