Clostridioides (previously clostridium) difficile is an inescapable problem within the critical care arena. This may arise as a nosocomial complication, in which case it is usually diagnosed early and treated successfully. It may also be the primary cause of admission to the ICU, in which case it is generally more severe.
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Opinion on PPI / H2 blocker use for C. Diff patients in ICU?
the PEPTIC trial showed that PPIs don’t actually increase the rate of C. diff.
PPIs have been correlated with lots of bad things since they are often utilized by multimorbid patients. I don’t think PPI-vs-H2 blocker actually affects C. Diff rates.