Invasive pulmonary aspergillosis was traditionally conceptualized as a rare infection restricted to profoundly immunocompromised patients. However, over the past decade, it's become increasingly clear that invasive aspergillosis can also occur as a nosocomial superinfection among patients who aren't immunocompromised (especially following influenza). This opens a can of worms regarding how to sift out colonization versus invasive infection, among critically ill patients who are usually unable to undergo tissue biopsy.
The IBCC chapter is located here.
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