The importance of avoiding and treating renal failure cannot be overstated. The kidneys are delicate organs, often the first to be injured by systemic hypoperfusion or other insults. Severe renal dysfunction leads to a cascade of badness, promoting the failure of other organs and eventual spiraling into multi-organ failure.1 Alternatively, if we are can defend a patient's renal function and avoid volume overload, then we will probably improve their prognosis substantially.
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The IBCC chapter is located here.
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Hi Josh,
Great Chapter!
One thing, aren’t TTP, HUS and hypertensive crisis rather intrarenal causes of AKI?
Regards,
Lukas.
Dear Josh, thanks for your great blog. I think i just noticed one error in unit conversion, 0.5cc (as written in text) are 5ml, AKI is defined as <0.5ml, that would ve cubic millimeters, not cubic centimeters. Otherwise again an extremly helpful article!
Hi, Recently discovered your blog and podcasts and loving working through your posts, thank you. Important (though possibly pedantic) points regarding including ACEi and ARB in list of ‘nephrotoxins’ (see link below for the original, longer argument) – technically they have a reversible haemodynamic action upon GFR which is not associated with markers of tubular injury, so are not truly nephrotoxic (like gentamicin or cisplatin). – the most common reason for re-admission after AKI in UK is pulmonary oedema. It is hypothesised that doctor fear of restarting the ACEi/ARB after AKI due to risk of ‘nephrotoxicity’ could be contributary to… Read more »
Dear Dr Farkus, The Internet Book of Critical Care is the most amazing educational & Point of Care asset ever. Love your teaching and the podcast with Adam- I don’t where to ask questions so I’m writing to you here Question -on the AKI lecture -you said non oliguric doesn’t respond to fluids-so are you saying just treat the”Red October” but don’t give any fluids? If you give fluids like LR (if not acidic)at what rate, obviously not 150/hr but what rate would you suggest ? Another related question -you said non oliguric AKI doesn’t respond to fluids. Question- with… Read more »
Hi! Are you planning a chapter on CRRT?