OK, interesting information. I just administered Ondansetron 4 mg IVP to my patient I am sedating just now. Some 15 years ago, I was privy to an unusual side effect of Ondansetron in a patient I cared for that underwent anterior cervical discectomy and fusion. He was a tall, thin gentleman in his early 40’s with a history of herniated cervical discs. Surgical procedure, airway management and anesthetic was unremarkable, and I was making a brief visit to the patient the afternoon of postop day 1 when the story gets interesting. The patient was recovering well, and had just returned from physical therapy when I paid him a visit postop day 1. He was otherwise without complaint, save for feeling nauseated. I reassured him, ordered Ondansetron 4 mg IV for nausea, and took my leave for the doctors’ locker room to change out of scrubs and leave the hospital. As I was exiting the hospital, a cardio-pulmonary arrest alert was called over the hospital PA system to that patient’s room. I ran up to assist with the crisis, and found the patient receiving bag-valve-mask ventilation from a respiratory therapist, patient visibly awake, with eyes wide open in terror. I slid… Read more »