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EMCrit 266 – High Sensitivity Troponins with Louise Cullen

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Today on the podcast we discuss High Sensitivity Troponins with Dr. Louise Cullen…

Professor Louise Cullen

Louise Cullen is a Senior Staff Specialist in the Department of Emergency Medicine, Royal Brisbane and Women’s Hospital, and an active clinician-researcher with particular interests in acute cardiac diseases, syncope, and cardiac biomarkers. She is widely published in numerous peer-reviewed journal including the Lancet. Her mantra is that “You do not do research for research sake” and as such, clinical redesign and translational research is a key part of her endeavours.

 COI

Dr. Cullen reports receiving grants from Roche; grants, consultancy fees, and personal fees from Abbott Diagnostics; personal fees from AstraZeneca; and personal fees from Novartis outside of the submitted work.

We have resolved these conflicts by:

  1. Not speaking of any individual manufacturer's assays

  2. In the US, the manufacturers are eliminating prior assays, thereby obviating the conflict of discussing hsTN (i.e. there will be no purchasing decision on your part–you're getting 'em whether you like it or not)

High Sensitivity Troponins

IFCC has released a lab spec sheet on troponins

Troponin values must be individualized based on your hospital's assay

ACS Decision Aides

Other FOAM

Additional New Information

Zhou Algo

Algorithm from Zhou et al. Actual cutoffs must be adapted to your assay

from this paper by Zhou et al. [How to Create a hs-troponin pathway]

Actual Clearance of Troponin

Real Half-Life of Troponin
Half-Life and Clearance of Cardiac Troponin I and Troponin T in Humans. Circulation. 2024 Oct 8;150(15):1187-1198. doi: 10.1161/CIRCULATIONAHA.123.066565. Epub 2024 Sep 10. PMID: 39253802

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Scott Weingart, MD FCCM
Latest posts by Scott Weingart, MD FCCM (see all)

Cite this post as:

Scott Weingart, MD FCCM. EMCrit 266 – High Sensitivity Troponins with Louise Cullen. EMCrit Blog. Published on February 20, 2020. Accessed on March 20th 2025. Available at [https://emcrit.org/emcrit/high-sensitivity-troponins/ ].

Financial Disclosures:

The course director, Dr. Scott D. Weingart MD FCCM, reports no relevant financial relationships with ineligible companies. This episode’s speaker(s) report no relevant financial relationships with ineligible companies unless listed above.

CME Review

Original Release: February 20, 2020
Date of Most Recent Review: Jul 1, 2024
Termination Date: Jul 1, 2027

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Dai software
Dai software
5 years ago

very interesting , good job and thanks for sharing such a good information
on demand service app development

What's Your Job?
zs
0
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Vickie Delise
Vickie Delise
3 years ago

troponin 4 value safe

What's Your Job?
retired
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We are the EMCrit Project, a team of independent medical bloggers and podcasters joined together by our common love of cutting-edge care, iconoclastic ramblings, and FOAM.

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