Question: Perampanel is an oral antiseizure medication that may occasionally be used for refractory status epilepticus. It has a half-life of 105 hours. Different sources recommend three different regimens for its dosing: (a) 18-24 mg load followed by 12 mg/day.(33830480) (b) 32 mg load followed by 12 mg/day.(31565443) (c) 36 mg on day #1, 24 […]
IBNCC – External Ventricular Drains (EVD) & Lumbar Drains
External ventricular drains and lumbar drains will generally be managed primarily by the neurosurgical team. Nonetheless, some general understanding of their management, data interpretation, and potential complications is extremely helpful. The IBCC chapter is located 👉 here. The podcast & comments are below. Follow us on iTunes
IBNCC – Neurological complications of COVID
The neurological manifestations of COVID is a rapidly moving target. Different strains of virus, rising levels of immunity, and challenges in sorting out causation from correlation make it impossible to write a perfect chapter on this. Nonetheless, some patterns and concepts may be helpful. The IBCC chapter is located 👉 here. The podcast & comments […]
IBNCC – Acute Demyelinating Disorders
Acute demyelinating disorders are not a common cause of ICU admission. However, these are encountered occasionally (especially acute transverse myelitis, acute disseminated encephalomyelitis, and osmotic demyelination syndrome). Additionally, some of these disorders may be triggered by COVID, so this chapter will help us understand the neurological manifestations of COVID. The IBCC chapter is located 👉 […]
IBNCC – EEG interpretation and ictal-interictal continuum
EEG is an increasingly utilized tool among critically ill patients. This chapter explores how to interpret the clinical significance of various EEG patterns which are commonly encountered in the ICU. The IBCC chapter is located 👉 here. The podcast & comments are below. Follow us on iTunes
IBNCC – Neuro-oncology emergencies
Neuro-oncologic emergencies are commonly encountered in critical care. Rapidly evolving biological therapies for cancer offer patients exciting benefits, but have also created new sets of complications (e.g., checkpoint inhibitor-induced encephalitis). Patients may be suffering from complications of the malignancy itself, complications of therapy, or wholly unrelated problems. The IBCC chapter is located 👉 here. The […]
PulmCrit – Systemic racism of pulse oximetry: Even worse than we thought?
One and a half years ago, a landmark study by Sjoding et al. found that critically ill Black patients were more likely than White patients to have falsely reassuring pulse oximetry measurements (discussed here).1 Subsequently, six sizable studies have been published on this topic. Since this is of critical importance to acute care medicine, it’s […]
IBNCC – Movement disorder emergencies
Movement disorders are encountered more frequently in the critical care unit than one might realize. For example Parkinson’s disease alone affects ~1% of patients over sixty years old (often requiring careful consideration in medication management, to avoid either psychosis or Parkinsonism-hyperpyrexia syndrome). Other disorders are less common, but their recognition may be critical (e.g., propofol […]
IBNCC – Cervical artery dissection
Carotid or vertebral artery dissection are important considerations in trauma and also common causes of ischemic stroke among younger patients. Variable presentations and a plethora of different diagnostic modalities can make this tricky. The IBCC chapter is located 👉 here. The podcast & comments are below. Follow us on iTunes
IBNCC – Neurologic emergencies in pregnancy
Neurologic emergencies in pregnancy are challenging as there is very little high-quality evidence regarding them. This chapter attempts to review available information, but large gaps remain. Ideally, such gaps may be filled by using multidisciplinary teams which personalize care for each individual patient. The IBCC chapter is located 👉 here. The podcast & comments are […]
IBNCC – Catatonia
Catatonia is an important cause of altered mental status which is often overlooked among critically ill patients. Although traditionally associated with schizophrenia, catatonia can result from a variety of psychiatric, neurologic, and medical problems (similar to delirium). It is important to diagnose catatonia, because otherwise patients are likely to be incorrectly labeled as having delirium […]
IBNCC – Neurogenic Pulmonary Edema
Neurogenic pulmonary edema isn’t particularly common, but it’s probably more common than we realize. Most cases are likely mistaken as cardiogenic pulmonary edema or aspiration pneumonitis. Treatment is predominantly supportive, with a focus on defending the injured brain (rather than focusing too much on the lungs). The IBCC chapter is located 👉 here. The podcast […]
IBNCC – Spinal Epidural Abscess (SEA)
Spinal Epidural Abscess is rare, but it is increasingly encountered (especially within the context of the opioid epidemic, and an aging population with increasing comorbidity). SEA may be part of the patient’s initial presentation to the ICU, or it may arise during the course of a prolonged ICU admission. The IBCC chapter is located 👉 […]
IBNCC – Baclofen intoxication & withdrawal
Baclofen is one of the most effective treatments for spasticity, but also perhaps the most toxic. Baclofen intoxication may lead to severe mental status suppression requiring intubation and occasionally hemodialysis. However, intrathecal baclofen withdrawal is more difficult to treat if it’s not possible to immediately re-institute intrathecal therapy. The IBCC chapter is located 👉 here. […]
Introducing the Internet Book of NeuroCritical Care (IBNCC)
Friends, Over the next several months we’ll be adding ~26 additional chapters to the neurology section of the IBCC. The ultimate goal is to create a complete neurocritical care textbook that is fully integrated into the IBCC. (You can preview the final table of contents here.) Why more neurocrit? The brain is one of the […]
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