by Andrew Stolbach The history of cancer therapy is entwined with the history of the 20th and 21st centuries. Scientific discovery does not occur in a historical vacuum. The swirl of world events does not stop outside the laboratory. In 1910, as Viennese researchers Ernest Freund and Gisa Kaminer published observations that some substance in […]
Tox and Hound – U(ds) and I
by Howard Greller Recently, I’ve moved offices, and came across a number of old letters. A lot of it was just regular business stuff (e.g., credentialing packets, requests for privileges, a metric ton of menus, etc.), but there was a significant amount of correspondence as well, including some letters of a personal nature. In lieu […]
Tox and Hound – Unconscious Uncoupling – Managing pH in Salicylate Overdoses
by Dan Rusyniak When Gwyneth Paltrow “consciously uncoupled” from Chris Martin, I immediately thought of mitochondria. Why mitochondria? For one because mitochondria are the favorite organelle of toxicologists (sorry, sarcoplasmic reticulum . . .). And second, because I am fascinated by drugs that uncouple oxidative phosphorylation. There are lots of toxins that target mitochondria. There […]
The Dantastic Mr. Tox & Howard – S02E09 – The Ascetic Arachnid
NOT RECLUSE with Dr. Rick Vetter Join Dan (@drusyniak) &Howard (@heshiegreshie) as they speak with Dr. Rick Vetter about all things brown recluse, why you should always inspect your packages very, very carefully, and why Howard will never move to Kansas. Delicious Links The USPS should be known as “The Fearless” . . . Arachnids […]
Tox and Hound – Fellow Friday – Rapid Collapse and Anaphylactoid Reactions from Rattlesnake Bites
by Steve Curry, M.D. Banner – University Medical Center Phoenix University of Arizona College of Medicine – Phoenix Phoenix, AZ @SteveCurryMD It’s early March in Phoenix and we are well into the rattlesnake bite season. It is estimated there are about 350 to 400 rattlesnake bites annually in Arizona, which is pretty tiny compared to […]
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