Resistance to fluoroquinolones is rapidly increasing
Traditional antibiograms are misleading when designing combination therapy
Combination antibiograms reveal that fluoroquinolones add little to beta-lactams
Potential harm of double coverage
Clinical evidence for double-coverage in ventilator-associated pneumonia?
What do the guidelines say?
(1) The patient was isolated with Ebola-like intensity and ultimately made a complete recovery. Carbapenem-resistant enterobacteriaceae were not seen in the ICU for some years after the patient's departure.
MD Anderson 2012: Smith et al.
Texas 2008-2012: Thurman 2014
U. Chicago 1999-2005: Christoff 2010
U. Nebraska 2008-2011
U. Penn 1999: Mizuta 2006
U. Wisconsin 2004-2006: Fox 2008
Wake Forest 2004: Beardsley 2006
Wash U. St Louis 2002-2006: Micek 2010